From February to December 2022 the iSSI®️ (intelligent Space System Interface) Modular Coupling Kit by iBOSS has being demonstrated and tested in orbit aboard the International Space Station ISS – on its external KIBO platform. This US mission has been conducted by Skycorp Incorporated in collaboration with SpaceBD, ISS National Lab and NASA and, and funded by the Defense Innovation Unit DIU. For the first time continuous long-term power and data transfer as well as ad-hoc testing of various coupling scenarios of such multi-functional and modular space connector have been demonstrated. The award-winning iSSI®️ with its unparalleled features is THE connector for ISAM (in-orbit servicing, assembly and manufacturing) paving the way for ultimate Plug & Play in space to support the development of future space infrastructure and associated logistics.